The storm snapped trees in the area even hit badly lives of 1 million people.
Hurling 130 mph winds, the Category 4 storm made landfall on Cudjoe Key, the National Hurricane Center was quoted as saying in CNN report.
According to reports, more than 1 million homes are currently without fire.
NWS Key West tweeted: "11:45a - While the Eye is north of the Keys, Wind (50-60mph sustained, gusts 70-90+) and Surge (5-10ft) threat continues through afternoon."
Florida Governor Rick Scott said every Floridian and visitor should stay safe and prepare for the storm.
He had earlier tweeted: "Life threatening storm surge is occurring now in the Keys and is expected to begin this morning in Southwest Florida."