The bus caught fire after colliding with the tanker.
"Four people, traveling on the roof top of the bus, remained safe after they jumped from the vehicle when it hit the tanker,"Pakistan's Geo News reported.
The accident occurred at Link Road near Gulshan-e-Hadeed.
According to initial report, the accident occurred due to the negligence of oil tanker driver, who escaped from the site after the accident.
Jinnah Post Graduate Medical Centre (JPMC) emergency department incharge Seemi Jamali told Geo News that 57 bodies including women and four injured have been shifted to Jinnah Hospital, where emergency has been declared.