August 08, 2020 05:51 (IST)
Follow us:
facebook-white sharing button
twitter-white sharing button
instagram-white sharing button
youtube-white sharing button
Kashmir: Army soldier slipped to death near LoC in Kupwara | BJP MP Chikhalikar tests positive for Covid-19 | Sushant death probe: Rhea Chakraborty reaches ED office after postponement of summon plea rejected | India reports 62,538 cases, 886 fatalities in past 24 hours | India's COVID-19 cases breach 2 million mark

Nobel Prize in Medicine awarded to Yoshinori Ohsumi

India Blooms News Service | | 03 Oct 2016, 03:45 pm
The Nobel Assembly at Karolinska Institutet on Monday decided to award the 2016 Nobel Prize in Physiology or Medicine to Yoshinori Ohsumi for his discoveries of mechanisms for autophagy.

The official Twitter page of the  The Nobel Prize ‏ tweeted quoting Ohsumi :”I was surprised. I was in my lab.”

This year's Nobel Laureate discovered and elucidated mechanisms underlying autophagy, a fundamental process for degrading and recycling cellular components. 

The word autophagy originates from the Greek words auto-, meaning "self", and phagein, meaning "to eat".


Thus,autophagy denotes "self eating". This concept emerged during the 1960's, when researchers first observed that the cell could destroy its own contents by enclosing it in membranes, forming sack-like vesicles that were transported to a recycling compartment, called the lysosome, for degradation, read an official statement.


Difficulties in studying the phenomenon meant that little was known until, in a series of brilliant experiments in the early 1990's,

Yoshinori Ohsumi used baker's yeast to identify genes essential for autophagy.


He then went on to elucidate the underlying mechanisms for autophagy in yeast and showed that similar sophisticated machinery is used in our cells.

Ohsumi's discoveries led to a new paradigm in our understanding of how the cell recycles its content.

His discoveries opened the path to understanding the fundamental importance of autophagy in many physiological processes, such as in the adaptation to starvation or response to infection.

Mutations in autophagy genes can cause disease, and the autophagic process is involved in several conditions including cancer and neurological disease.

 

Related Images
Kolkata witnesses 'supermoon' 01 Jan 1970, 05:30 am
Related Videos
Covid-19 press briefing by WHO 01 Jan 1970, 05:30 am
Covid-19 press briefing in India 01 Jan 1970, 05:30 am